LEUNG, Kwong-Sak Emeritus Professor, Computer Science & Engineering
Research Professor (2018-21)
(Chair) Professor of Computer Science & Engineering (2002-2018) Professor in
the CUHK-BGI Innovation Institution of
Trans-omics (2011-2018)
Associate Director, Institute of Future Cities (2013-2021)
Director, Urban Informatics Programme, IOFC (2014-2021)
B.Sc.(Eng), Ph.D.(Lond.), Distinguished Fellow HKCS,
FHKIE, SMIEEE, MIET, C.Eng.
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Dr. Leung is currently Emeritus Professor. He was Professor of Computer Science
& Engineering (Chair Professor) until 2018 and was appointed as
Professor in the CUHK-BGI Innovation Institution of Trans-omics in the
Chinese University of Hong Kong. He was
Chairman of the Department from Aug 1999 to July 2005 and
the Head
of Graduate Division of Computer Science between April, 1992 and July,
1997. He worked as a senior engineer and system analyst at ERA
Technology
and the Headquarters computer centre of Central Electricity Generating
Board respectively in England for five years before joining the Chinese
University in August 1985. He has gained extensive experiences in
project
management and the development of large scale software for research and
simulation purposes.
Dr. Leung received his B.Sc. and Ph.D. degrees from the University
of
London in 1977 and 1980 respectively, and is a fellow of
HKIE, a member
of IET and ACM, a Life
senior member of IEEE and a chartered engineer. He was nominated to be
the Distinguished Fellow of Hong Kong Computer Society in
2000. He was one
of the founder members and the Chairman of ACM Hong Kong Chapter and a
Council member of Hong Kong Computer Society. He contributed
significantly in setting up the
Engineering Faculty as a member of the Planning & Implementation
Committee and all other 7 committees.
He served as a member of the Engineering Panel of the Research Grant
Council
of the University Grant Committee for 5 years (94-99). He was an
external
examiner of OUHK. Dr. Leung was member of Editorial Board for Fuzzy
Sets
and Systems (1999-2019) and the IT Magazine (94-98), associate editor
of
International Journal of Intelligent Automation and Soft Computing
(2001-2010).
He has served as chairman and member of numerous international
conference
organizing and programme committees. He was a member of the
University's
Research Committee and the Convener of Engineering Panel (96-00). He
has
authored and co-authored over 400 publications with an average impact
factor of >8.06 for the top 100 Journal papers and 4 books. His research
interests
are in the areas of knowledge engineering, bioinformatics, drug discovery, soft
computing, genetic
algorithms
and programming, automatic knowledge acquisition, fuzzy
logic
applications,
and AI architecture.
The numbers of MPhil and PhD students graduated under his supervision are 41 and 31 respectively.
Prof.
Leung is ranked among the world’s top 2% most-cited scientists
(subfields: Artificial Intelligence and Bioinformatics) in the 2021 and 2024
released metrics published by Stanford University for both the
career-long and single-year categories. (link)
Address: Department of Computer Science and Engineering,
The Chinese University of Hong Kong, Shatin, N.T. Hong Kong
- Knowledge Engineering
- Bioinformatics (Roadmap) & Data Mining
- Automatic Knowledge Acquisition
- Fuzzy Logic Applications
- Genetic Algorithms and Programming
- AI Architecture (Intelligent Sensor Systems, IoT)
DNA Patents
Drug Patents
Intelligent Sensor Patent
Books Published
- Z.Y. Wang, R. Yang
& K.S. Leung, NONLINEAR INTEGRALS AND
THEIR APPLICATIONS IN DATA MINING, June 2010, World Scientific
- M.L.
Wong and K.S. Leung, Data Mining Using Grammar Based Genetic
Programming
and Applications, Jan 2000, Kluwer Academic Publishers, Genetic
Programming
Series.
Representative Journal Publications: (student name) IF: impact factor (Full publication list Google Scholar)
- H Li, (X Zheng), J Gao, KS Leung, MH
Wong, S Yang, Y Liu, M Dong, H Bai, ...“Whole transcriptome analysis
reveals non-coding RNA's competing endogenous gene pairs as novel form
of motifs in serous ovarian cancer”. Computers in Biology and Medicine
148, 105881; 2022
- Q Wu, (X Zheng), KS Leung, MH Wong, SKW
Tsui, L Cheng. “meGPS: a multi-omics signature for hepatocellular
carcinoma detection integrating methylome and transcriptome data”. Bioinformatics (IF:6.93) 38 (14), 3513-3522; 2022
- (WY
Yi), PF Liu, SL Lo, YF Chan, Y Zhou, Y Leung, KS Woo, APW Lee, ...KS
Leung.”Towards Personalized Healthcare in Cardiac Population: The
Development of a Wearable ECG Monitoring System, an ECG Lossy
Compression Schema, and a ResNet-Based AF Detector”. arXiv preprint
arXiv:2207.05138; 2022
- (WY Yi), Y Zhou, YF Chan, Y Leung,
KS Woo, WW Che, KH Lau, JM Chen, ...KS Leung. “Field Evaluation of Four
Low-cost PM Sensors and Design, Development and Field Evaluation of A
Wearable PM Exposure Monitoring System”. arXiv preprint
arXiv:2207.05140; 2022
- (R Wang), (X Zheng), J Wang, S Wan,
F Song, MH Wong, KS Leung, ... ”Improving bulk RNA-seq classification
by transferring gene signature from single cells in acute myeloid
leukemia”. Briefings in Bioinformatics, (IF:13.994, rank 1/57) 23 (2), bbac002; 2022
- (X
Zheng), KS Leung, MH Wong, L Cheng. “Long non-coding RNA pairs to
assist in diagnosing sepsis”. BMC genomics 22 (1), 1-13; 2021
- Y
Zhu, KB Ke, ZK Xia, HJ Li, R Su, C Dong, FM Zhou, L Wang, R Chen, ...
“Discovery of vanoxerine dihydrochloride as a CDK2/4/6 triple-inhibitor
for the treatment of human hepatocellular carcinoma” Molecular Medicine
27 (1), 1-14 6; 2021
- H Li, G Lu, KH Sze,
X Su, WY Chan, KS Leung. “Machine-learning scoring functions trained on
complexes dissimilar to the test set already outperform classical
counterparts on a blind benchmark”. Briefings in bioinformatics 22 (6), bbab225; 2021
- Y
Yang, Y Zhang, (S Li), X Zheng, MH Wong, KS Leung, L Cheng. “A robust
and generalizable immune-related signature for sepsis diagnostics”.
IEEE/ACM Transactions on Computational Biology and Bioinformatics; 2021
- D
Huang, AYN Liu, KS Leung, NLS Tang. “Direct Measurement of B Lymphocyte
Gene Expression Biomarkers in Peripheral Blood Transcriptomics Enables
Early Prediction of Vaccine Seroconversion”. Genes 12 (7), 971; 2021
- (PK
Wong), ML Wong, KS Leung. “Probabilistic Contextual and Structural
Dependencies Learning in Grammar-Based Genetic Programming”.
Evolutionary Computation 29 (2), 239-268; 2021
- MC Yuen, I
King, KS Leung. “Temporal context-aware task recommendation in
crowdsourcing systems”. Knowledge-Based Systems 219, 106770;
2021
- L Cheng, (X Zheng), R Ling, J Gao,
KS Leung, MH Wong, S Yang, Y Liu, ... “Whole Transcriptome Analyses
Identify Pairwise Gene Circuit Motif in Serous Ovarian Cancer”. DOI:
https://doi.org/10.21203/rs.3.rs-422831/v1; 2021
- (X Zheng),
Q Wu, H Wu, KS Leung, MH Wong, X Liu, L Cheng. “Evaluating the
consistency of gene methylation in liver cancer using Bisulfite
sequencing data”. Frontiers in cell and developmental biology 9,
671302; 2021
- ZK Xia, W Wang, JG Qiu, XN Shi, HJ Li, R Chen,
KB Ke, C Dong, Y Zhu, ... “Discovery of a new CDK4/6 and PI3K/AKT
multiple kinase inhibitor aminoquinol for the treatment of
hepatocellular carcinoma”. Frontiers in pharmacology 12; 2021
- X
Liu, Y Xu, (R Wang), S Liu, J Wang, YL Luo, KS Leung, L Cheng. “A
network-based algorithm for the identification of moonlighting
noncoding RNAs and its application in sepsis”. Briefings in bioinformatics 22 (1), 581-588; 2021
- (KY
Lee), KS Leung, SL Ma, HC So, D Huang, NLS Tang, MH Wong. “Genome-wide
search for SNP interactions in GWAS data: Algorithm, feasibility,
replication using schizophrenia datasets”. Frontiers in genetics 11,
1003; 2020
- X Liu, (X Zheng), J Wang, N Zhang, KS Leung, X
Ye, L Cheng. “A long non‐coding RNA signature for diagnostic prediction
of sepsis upon ICU admission”’ Clinical and translational medicine 10
(3); 2020
- H Wang, X Tang, S Lai, KS Leung, J Zhu, GPC Fung, KF
Wong. “CUHK at semeval-2020 task 4: Commonsense explanation, reasoning
and prediction with multi-task learning”. arXiv preprint
arXiv:2006.09161; 2020
- X Liu, Y Xu, (R Wang), S Liu, J Wang, YL Luo, KS Leung, L
Cheng. “A network-based algorithm for the identification of moonlighting
noncoding RNAs and its application in sepsis”. Briefings in Bioinformatics, 2020 (IF:13.994, rank 1/57);
https://academic.oup.com/bib/advance-article/doi/10.1093/bib/bbz154/5718595
- (WY Yi), K Leung, Y Leung. “Air quality measurement with
modular sensor system and method”. US Patent 10,533,981, 1, 2020; https://patents.google.com/patent/US10533981B2/en
- (PK
Wong), KS Leung, ML Wong. “Probabilistic grammar-based neuroevolution
for physiological signal classification of ventricular tachycardia”.
Expert Systems with Applications 135, 237-248; 2019; (IF: 4.3) https://doi.org/10.1016/j.eswa.2019.06.012
- J
Qi, L Liu, B Xu, Z Shen, KS Leung, Y Sun. “Low-carbon Community
Adaptive Energy Management Optimization Toward Smart Services”. IEEE
Transactions on Industrial Informatics; 2019; (IF:7.38) https://doi.org/10.1109/TII.2019.2950511
- (R Wang), (S Li), L Cheng, MH Wong, KS Leung. “Predicting
associations among drugs, targets and diseases by tensor decomposition for drug
repositioning”. BMC bioinformatics 20 (26), 628, 2019; https://link.springer.com/article/10.1186/s12859-019-3283-6
- (P Liu), H Li, (S Li), KS Leung. “Improving prediction of
phenotypic drug response on cancer cell lines using deep convolutional network”.
BMC bioinformatics 20 (1), 408, 4, 2019; https://bmcbioinformatics.biomedcentral.com/articles/10.1186/s12859-019-2910-6L
- L Cheng, P Liu, D Wang, KS Leung. "Exploiting locational and topological overlap model to identify modules in protein interaction networks". BMC Bioinformatics 20 (1), 23; 2019; https://doi.org/10.1186/s12859-019-2598-7
- A Pe�n, H Li, G Ghislat, KS Leung, MH Wong, G Lu, PJ Ballester. "MolTarPred:
a web tool for comprehensive target prediction with reliability
estimation". Chemical biology & drug design; 3.2019; https://doi.org/10.1111/cbdd.13516
- H Li, J
Peng, P Sidorov, YLeung, KS Leung, ..."Classical scoring functions for
docking are unable to exploit large volumes of structural and
interaction data". Bioinformatics; 3.2019; https://doi.org/10.1093/bioinformatics/btz183
- (L
Cheng), KS Leung. "Identification and characterization of moonlighting
long non-coding RNAs based on RNA and protein interactome". Bioinformatics, 5.2018, (IF:7.3); https://doi.org/10.1093/bioinformatics/bty399J
- Qi,
C Lai, B Xu, Y Sun, KS Leung. "Collaborative Energy Management
Optimization Towards Green Energy Local Area Network". IEEE
Transactions on Industrial Informatics, Jan 2018, (IF:6,8); https://doi.org/10.1109/TII.2018.2796021
- Y
Leung, KS Leung, MH Wong, T Mak, KY Cheung, LY Lo, WY Yi, YL Dong.
"An integrated web-based air pollution decision support system – a
prototype". IJGIS; Apr 2018, https://doi.org/10.1080/13658816.2018.1460752
- KY Lee, KS Leung, NLS Tang, MH Wong. "Discovering
Genetic Factors for psoriasis through exhaustively searching for
significant second order SNP-SNP interactions". Scientific reports 8
(1), 15186; 2018.
- X Shi, H Li, A Shi, H Yao, K Ke, C Dong, Y Zhu, Y Qin, Y Ding, YH He, ..."Discovery of rafoxanide as a dual CDK4/6 inhibitor for the treatment of skin cancer". Oncology reports 40 (3), 1592-1600; 2018.
- B Xu, J Qi, X Hu, KS Leung, Y Sun, Y Xue.
"Self-adaptive bat algorithm for large scale cloud manufacturing
service composition". Peer-to-Peer Networking and Applications 11 (5),
1115-1128; 2018.
- H Li, J Peng, Y Leung, KS Leung, MH Wong, G Lu, P Ballester. "The
impact of protein structure and sequence similarity on the accuracy of
machine-learning scoring functions for binding affinity prediction".
Biomolecules 8 (1), 12; 2018.
- KM Lo, WY Yi, PK Wong, KS Leung, Y Leung, ST Mak. "A
genetic algorithm with new local operators for multiple traveling
salesman problems". International Journal of Computational Intelligence
Systems 11 (1), 692-705; 2018
- (L Cheng), KS Leung. “Quantification of non-coding RNA
target localization diversity and its application in cancers”. Journal of
Molecular Cell Biology, 1.2018.(IF:6.0) https://doi.org/10.1093/jmcb/mjy006
- (WY Yi), KS Leung, Y Leung. “A Modular Plug-And-Play
Sensor System for Urban Air Pollution Monitoring: Design, Implementation and
Evaluation”. Sensors 18 (1), 7; 2018
- C Dong, ..., KS Leung… “Econazole nitrate inhibits
PI3K activity and promotes apoptosis in lung cancer cells”. Scientific reports
7 (1), 17987; 2017
- (L Cheng), P Liu, KS Leung. “SMILE: a novel procedure
for subcellular module identification with localisation expansion”. IET Systems
Biology; 2017
- Y Niu, H Li, L Gao, H Lin, H Kung, MC Lin, KS Leung,
MH Wong, W Xiong, ... “Old drug, new indication: Olsalazine sodium reduced
serum uric acid levels in mice via inhibiting xanthine oxidoreductase activity”.
Journal of pharmacological sciences 135 (3), 114-120; 2017
-
(L Cheng), K Fan, Y Huang, D Wang, KS Leung. “Full
characterization of localization diversity in the human protein Interactome”. Journal
of proteome research 16 (8), 3019-3029;
2017. DOI: 10.1021/acs.jproteome.7b00306
- K Ke, H Li, H Yao, XN Shi, C Dong, Y Zhu, X Liu, L Li,
KS Leung, ... “In silico prediction and in vitro and in vivo validation of
acaricide fluazuron as a potential inhibitor of FGFR3 and a candidate
anticancer drug for bladder carcinoma”. Chemical biology & drug design 89
(4), 505-513 4; 2017
- ESA Lee, HYA Sze-To, MH Wong, KS Leung, TCK Lau, AKC
Wong. “Discovering protein-dna binding cores by aligned pattern clustering”. IEEE/ACM
transactions on computational biology and bioinformatics 14 (2); 254-263; 2017
- H Li, CWS Tong, Y Leung, MH Wong, KKW To, KS Leung. “Identification
of clinically approved drugs indacaterol and canagliflozin for repurposing to
treat EGFR tyrosine kinase inhibitors-resistant lung cancer”. Frontiers in
oncology 7, 288; 2017
- B Xu, J Qi, X Hu, KS Leung, Y Sun, Y Xue. “Self-adaptive
bat algorithm for large scale cloud manufacturing service composition”. Peer-to-Peer
Networking and Applications, 1-14; 2017
- (MC Yuen), I King, KS Leung. “An online-updating
algorithm on probabilistic matrix factorization with active learning for task
recommendation in crowdsourcing systems” Big Data Analytics 1 (1), 14; 2016
- Y Liang, H Chai, XY Liu, ZB Xu, H Zhang, KS Leung. “Cancer
survival analysis using semi-supervised learning method based on cox and aft
models with l 1/2 regularization”. BMC medical genomics 9 (1), 11; 2016
- HJ Li, KS Leung, MH Wong and PJ Ballester. "USR-VS: a web server
for large-scale prospective virtual screening using ultrafast shape
recognition techniques". Nucleic Acids Research, 2016. (IF:10.162) DOI: 10.1093/nar/gkw320
- HJ Li, KS Leung, MH Wong and PJ Ballester. "Correcting the impact
of docking pose generation error on binding affinity prediction". BMC
Bioinformatics, 17 (11), 308; 2016.
- (LY Lo), ML Wong, KH Lee, KS Leung "High-order dynamic Bayesian
Network learning with hidden common causes for causal gene regulatory
network". BMC Boinformatics 16
(1), 1
- (LY Lo), ML Wong, KH Lee, KS Leung. "Time Delayed Causal Gene
Regulatory Network Inference with Hidden Common Causes". PloS ONE, 2015, 10 (9), e0138596
- XN Shi, HJ Li, H
Yao, X Liu, LLi, KS Leung, HF Kung, D Lu, MH Wong, and Marie CM Lin. In
silico Identification and in vitro and in vivo Validation of
Anti-Psychotic Drug Fluspirilene as a Potential CDK2 Inhibitor and a
Candidate Anti-Cancer Drug. PLoS ONE, 10(7):e0132072, 2015. DOI:
10.1371/journal.pone.0132072
- HJ Li, KS Leung, MH Wong and PJ.
Ballester. Low-Quality Structural and Interaction Data Improves Binding
Affinity Prediction via Random Forest. Molecules,
20(6):10947-10962, 2015. DOI:
10.3390/molecules200610947
- (Peter LY Lo), KS Leung and
KH Lee, "Inferring Time-Delayed Causal Gene Network using Time-series
Expression Data ", IEEE/ACM
Transaction on
Computational Biology and Bioinformatics, 2015.Vol. 12, Issue 1,142-154
- (HJ Li), KS Leung1, MH
Wong1 and PJ Ballester. “Improving AutoDock Vina Using Random
Forest: The Growing Accuracy of Binding Affinity Prediction by the
Effective Exploitation of Larger Data Sets.” Molecular Informatics,
Article first published online: 12 FEB 2015, DOI:
10.1002/minf.201400132
- XN Shi, (HJ L)i, H Yao, X
Liu, L Li, KS Leung, HF Kung, MH Wong, and Marie CM Lin. "Adapalene
Inhibited the Activity of Cyclin-Dependent Kinase 2 in Colorectal
Carcinoma". Molecular Medicine Reports.12(5):6501-6508, 2015. DOI:
10.3892/mmr.2015.4310
- (HJ Li), KS Leung, MH Wong
and PJ Ballester,"Substituting Random Forest for Multiple Linear
Regression Improves Binding Affinity Prediction of Scoring Functions:
Cyscore as a Case Study", BMC Bioinformatics,
2014, 15(1):291 DOI:
10.1186/1471-2105-15-291
- MH Wong, (HY Sze-To), (LY
Lo), TM Chan, and KS Leung. "Discovering Binding Cores in Protein-DNA
Binding Using Association Rule Mining with Statistical Measures",
IEEE/ACM Transaction on
Computational Biology and Bioinformatics, 2014. DOI:
10.1109/TCBB.2014.2343952
- (HJ Li), KS Leung, T Nakane
and MH Wong. "iview: an interactive WebGL visualizer for protein-ligand
complex". BMC Bioinformatics,
15(1):56, 2014. DOI:
10.1186/1471-2105-15-56
- (HJ Li), KS Leung, P.
Ballester, MH Wong. "istar: A Web Platform for Large-Scale
Protein-Ligand Docking", PLoS ONE 9(1): e85678, 2014. DOI:
10.1371/journal.pone.0085678
- TM Chan, LY Lo, HY Sze-To,
KS Leung, X Xiao, and MH Wong, "Modeling Associated
Protein-DNA Pattern
Discovery with Unified Scores", IEEE/ACM
Transaction on
Computational Biology and Bioinformatics. 10(3) 696-707, May/June 2013.
- Y Liang, C Liu, XZ Luan, KS
Leung, TM Chan, ZB Xu, H Zhang. "Sparse logistic regression with a L1/2
penalty for gene selection in cancer classification", BMC Bioinformatics 14 (1), 198, 2013
- T.M. Chan, K.S. Leung, K.H.
Lee, M.H. Wong 1, C.K. Lau , Stephen K.W. Tsui, Subtypes
of Associated Protein-DNA (Transcription Factor-Transcription Factor
Binding Site) Patterns, Nucleic Acids Research,
August 2012; doi: 10.1093/nar/gks749 ; (IF:10.162)
- T.M. Chan, K.S. Leung, K.H. Lee,
Memetic Algorithms for de novo Motif Discovery. IEEE Transactions on
Evolutionary Computation, 2012, 16(5), pp. 730-748.(IF:10.629)
- T.M. Chan, K.C. Wong, K.H. Lee, M.H.
Wong, C.K. Lau, Stephen K.W. Tsui, K.S. Leung, Discovering approximate-associated sequence
patterns for protein-DNA interactions. Bioinformatics, 2011, 27(4), pp. 471-478.
(IF:7.307)
- (S.K. LOU), J.W. LI, H. QIN, Aldrin K.Y. YIM, L.Y. Lo, Bing Ni,
K.S. Leung, Stephen K.W. TSUI, and T.F. CHAN, "Detection of splicing
events and multiread locations from RNA-seq data based on a
geometric-tail (GT) distribution of intron length", BMC Bioinformatics,
2011.07.27, Vol.12 suppl.5 S2.
- Y Liang and KS Leung "Genetic
Algorithm with adaptive elitist-population strategies for multimodal
function optimization", Applied Soft Computing 11 (2011) 2017–2034
- Leung, KS, (Wong, KC),
(Chan, TM), Wong, MH, Lee, KH, Lau, CK,
and
Tsui, Stephen, "Discovering
Protein-DNA Binding Sequence Patterns Using
Association Rule Mining," Nucleic
Acids Research. , 2010, 38(19), pp. 6324-6337. (IF:10.162)
Among NAR Top Articles - Computational Biology, as in Oct-Dec 2011
- (S.K. Lou)†, (B. Ni)†, L.Y. Lo, Stephen K.W. Tsui, T.F. Chan and
K.S.
Leung, "ABMapper:
a suffix array-based tool for multi-location
searching and splice-junction mapping", Bioinformatics, Oxford Journal,
2010.02.01 †co-1st authors (IF: 7.307)
- (T.M. Chan), (G. Li), K.S. Leung and K.H.Lee, Discovering
multiple realistic TFBS motifs based on a generalized model, BMC Bioinformatics, 2009, 10:321.
- (G. Li), (T.M. Chan), K.S. Leung and K.H.Lee, A
Cluster Refinement Algorithm for Motif Discovery, IEEE/ACM Transaction on
Computational Biology and Bioinformatics. pp.654-668., 2010.10.01
- KS Leung,
KH Lee, (JF
Wang), (Eddie
YT Ng), Henry LY Chan, Stephen KW Tsui, Tony SK Mok, C.H. Tse,
Joseph JY
Sung, “Data
Mining on DNA Sequences
of Hepatitis B Virus”. IEEE/ACM Transactions on
Computational Biology and Bioinformatics. vol.8
no.2, pp.428-40. 2011.03.
- (Chan, T.M.), Leung, K.S., and Lee, K.H., “ TFBS identification based on genetic algorithm with
combined representations and adaptive post-processing.” Bioinformatics, Vol.24,
No.3, pp341-349, Oxford Journals, Feb 2008. (IF: 7.307)
- (Rong Yang), Z.Y. Wang, P.A. Heng, and K.S. Leung, “Fuzzified
Choquet integral with fuzzy-valued integrand and its application on
temperature prediction,” IEEE Trans.
SMCB, Vol.38, no.2, pp367-380, April 2008.
- (S. M. Cheang), K. H. Lee and K.S. Leung “Applying Genetic
Parallel Programming to Synthesize Combinational Logic Circuits,” IEEE Transactions on Evolutionary
Computation, Vol.11, No.4, pp.503-520,
August 2007. (IF: 10.629)
- (Rong Yang), Z.Y. Wang, P.A. Heng, and K.S. Leung,
“Classification of
Heterogeneous Fuzzy Data by Choquet Integral With
Fuzzy-Valued Integrand”, IEEE
Transactions on Fuzzy
Systems, Vol.15, No5, pp.931-942, Oct 2007. (IF: 7.671)
- Joseph JY Sung, KW Tsui, CH Tse, Eddie YT Ng, KS Leung, KH Lee,
Tony SK Mok, A. Bartholomeusz, CC Au, S Locarnini, Henry LY Chan “Genotype-Specific
Genomic Markers Associated with Primary Hepatoma
Based on Complete Genomic Sequencing of Hepatitis B Virus,” Journal
of Virology, vol.82, no.7, pp3604-3611, Apr. 2008.( IF:4.648) (GWAS paper)
- L. Zhu,
C.H. Tse, Vincent W.S. Wong, Angel M.L. Chim, K.S. Leung, Henry
LY Chan “A Complete Genomic Analysis Of Hepatitis B Virus Genotypes And
Mutations In Hbeag-Negative Chronic Hepatitis B In China,” The Journal
of Viral Hepatitis, 2008;15(6):449-458. (IP 3.307)
- Henry L.Y. Chan, C.H. Tse, (Eddie Y.T. Ng), K.S. Leung , K.H.
Lee,
K.W. Tsui , Joseph J. Y. Sung “Phylogenetic, Virological and Clinical
Characteristics of Genotype C Hepatitis B Virus with TCC at Codon 15 of
the Precore Region,” Journal of Clinical Microbiology, Vol.44, No.3,
pp.681-687, (impact factor 4.232, 23 of 119 in
Microbiology).11.
- (S. M. Tse), Y. Liang, K. S. Leung, K. H. Lee and Tony S. K. Mok,
"A Memetic
Algorithm for Multiple Drugs Cancer Chemotherapy Schedule
Optimization," IEEE
Transactions on Systems, Man and Cybernetics - Part B, vol. 37, no. 1,
pp.84-91, Feb. 2007. (IF: 7.384)
- Z. Wang, K.S. Leung, and G. J. Klir, “Integration on finite
sets,” International Journal of Intelligent Systems, 21 (10),
1073-1092, 2006
- K.S. Leung, Irwin King, and (Y.B. Wong) “A probabilistic
cooperative-competitive hierarchical model for global optimization.”
Journal of Applied Mathematics and Computation, 175 (2006) 1092-1124
- (S. M. Cheang), K.S. Leung and K. H. Lee “Genetic Parallel
Programming: Design and Implementation,” Evolutionary Computation
(MIT-Press), Vol. 14 Issue 2, pp. 129-156, 2006
- (Liang
Y.), Leung K.S. and Tony Mok S.K. "A Novel Evolutionary Drug
Scheduling Model in Cancer Chemotherapy," IEEE Transactions on
Information Technology in Biomedicine, Vol.10, No.2, pp.237-245, April,
2006.
- P.A. Heng, T.T. Wong, (R. Yang), Y.P. Chui, Y M, Xie, K.S. Leung
and P.C. Leung, “Intelligent Interfering and Haptic Simulation for
Chinese Acupuncture Learning and Training,” IEEE Transactions on Information
Technology in Biomedicine, Vol.10, No.1, pp.28-41, Jan., 2006.
- (H.-D.
Jin), M.-L. Wong, and K.-S. Leung, “Scalable Model-based
Clustering for Large Databases Based on Data Summarization”, IEEE
Transactions on Pattern Analysis and Machine Intelligence, vol. 27, no
11, pp.1710-1719, Nov. 2005. (IF: 8.329)
- (Y.Liang)
and K.S.Leung, “Evolution Strategies with
Exclusion-based Selection Operators and a Fourier Series Auxiliary
Function”, Applied Mathematics and Computation,
174, pp.1080-1109, 2006.
- Z. Wang, (Rong Yang), P. Heng, and K.S. Leung, “Real-valued
Choquet integrals with fuzzy-valued integrand”, Fuzzy Sets and Systems,
Vol.157, No. 2, pp, 256-269, Jan. 2006.
- (Rong Yang), Z. Wang,
P.A. Heng, and K.S. Leung, “Fuzzy numbers and fuzzification of
Choquet integrals”, Fuzzy Sets and
Systems, 153 , 95-113, 2005.
- (H.-D. Jin), K.S. Leung, M.-L. Wong, and Z.-B. Xu, “Scalable
Model-based Clustering of Large Data Sets: Working on Clustering
Features,” Pattern Recognition, Vol.38, pp.637-649, 2005.
- M.L. Wong and K.S. Leung, "An Efficient Data Mining Method for
Learning Bayesian Network Using an Evolutionary Algorithm-Based Hybrid
Approach", IEEE Transactions
on Evolutionary Computation, Vol.8, No.4,
pp.378-404, August 2004. (IF: 10.629)
- K.S. Leung, (Z.Y. Zhu) and Xu Z.B. “Multi-Objective Optimization
Using Non-dominated Sorting Annealing Genetic Algorithms,” Asian
Information-Science-Life, Vol1, No.3, pp.211-230, 2003
- M.L. Wong, ( S. Y. Lee) and K.S. Leung "Data Mining of Bayesian
Networks Using Cooperative Co-evolution" Decision Support Systems
and Electronic Commerce. 38, pp. 451-472.
- (Y.Y. Wong), K.H. Lee, K.S.
Leung, (C.W.
Ho.) "A novel approach in parameter adaptation and diversity
maintenance
for genetic algorithm." Soft Computing, Vol.7, No.8, pp.506-515, August
2003.
- (Y.W. Lee), K.S. Leung, and
M.
Satyanarayanan
"Operation Shipping for Mobile File Systems", IEEE Transactions on
Computers. Vol.51, No.12 pp.1410-1422, December 2002
- K.S. Leung, M.L. Wong, W.
Lam,
Z.Y.
Wang and K.B. Xu "Learning Nonlinear Multiregression Networks Based on
Evolutionary Computation", IEEE
Transactions on Systems, Man and
Cybernetics
Part B, Vol.32, No.5, pp.630-644, October 2002. (IF: 7.384)
- (Y.Y. Wong), K.S. Leung, and
K.H. Lee
"Stochastic load balancing algorithm for i-Computing," Concurrency and
Computation: Practice and Experience, 15(1), 55-78, Jan. 2003.
- (Xu K.B.), Wang Z.Y., Wong M.L. and Leung K.S. "Discover
Dependency
Pattern
Among Attributes By Using A New Type of Nonlinear Regression"
International
Journal of Intelligent Systems, Vol. 16, pp.949-962, John Wiley &
Sons,
2001
- (Y.C. Wong), K.S. Leung and C.K. Wong, "Simulated
Annealing-Based
Algorithms for the Studies of the Thermoelastic Scaling Behavior" IEEE
Transaction on System, Man, Cybernetic. Vol.30, No.4, pp.506-516, Nov.
2000. (IF: 7.384)
- Wong M. L., Leung K. S., and Cheng J. C. Y. "Discovering
Knowledge
from Noisy Databases using Genetic Programming," Journal of the
American
Society for Information Science, Vol.51, No.9, pp.870-881, 2000.
- Wang Z.Y. , Leung K.S. and Wang J., "A genetic
algorithm
used
for determining nonadditive set functions in information fusion," Fuzzy
Sets and Systems. 102 (1999), pp.463-469.
- Y. Leung, Leung K. S. and J. Z. He. "A generic
concept-based
object-oriented
geographical information system". International Journal of
Geographical
Information Science, Vol. 13, No. 5, pp.475-498, Taylor &
Francis
Ltd, May1999
- Wong M.L., W. Lam and Leung K.S., "Using Evolutionary
Computation
and Minimum Description Length Principle for Data Mining of Bayesian
Networks" IEEE Transactions
on Pattern Analysis and Machine Intelligence. Vol.21, No.2,
pp.174-178,
1999. (IF: 8.329)
- Leung K. S., Lee K.H., & (Wong Y.Y.), "DJM: a Global
Distributed
Virtual Machine on Internet", Software - Practice and Experience,
Vol.28(12),
pp.1269-1297, Oct 1998.
- Wong M. L., Lam W., Leung K. S., Ngan P. S., and Cheng,
J. C.
Y.,
"Discovering Knowledge from Medical Databases Using Evolutionary
Algorithms" IEEE
Engineering in Medicine and Biology Magazine. Vol.19, No.4, pp.45-55,
July/Aug
2000.
- (Li Y.Y.), (Cheung S.K.), Leung K.S. and Wong C.K.,
"Steiner
Tree
Constructions in ?3-Metric", IEEE Transaction on Circuits and
Systems-II:
Analog and Digital Signal Processing, Vol. 45, No. 5, May 1998.
- Wong M.L. and Leung K.S. "Evolutionary Program Induction
Directed
by Logic Grammars" - Evolutionary Computation, Vol. 5, No. 2.,
pp.143-180,
MIT Press, 1997
- A. Albrecht, (S.K. Cheung), K.C. Hui, Leung K.S.,
and
C.K.
Wong. "Optimal Placements of Flexible Objects Part I (Analytical
Results
for the Unbounded Case)" - IEEE Transactions on Computers,
Vol.46,
No.8, pp.890-904, Aug., 1997.
- A. Albrecht, (S.K. Cheung), K.C. Hui, LeungK.S., and C.K.
Wong.
"Optimal Placements of Flexible Objects Part II (A Simulated Annealing
Approach for the Bounded Case)", IEEE Transactions on
Computers,
Vol.46, No.8, pp.905-929, Aug.,1997.
- (Chan W.K.), Leung K.S. and Wong W.S., "An Oject-Oriented
Knowledge
Based System for Image Diagnosis", Applied Artificial Intelligence,
published by Francis & Taylor, Vol.10, No.5, pp.407-438, 1996.
- Leung K.S., (Ji H. B.) and Leung Y. "Adaptive Weighted
Outer-Product
Learning Associative Memory" - IEEE Transactions on System,
Man
and Cybernetics, Vol.27, No.3, pp.533-543, June 1997. (IF: 7.384)
- (Wong, M. L.) and Leung, K.S. (1995). "Evolving recursive
functions
for the even-parity problem using genetic programming." In P. J.
Angeline
and K. E. Kinnear, Jr. (Eds.) Advances in Genetic Programming 2.,
Chapter 11, pp.221-240, MA: MIT Press, 1996.
- (Chan W.K.), Leung K. S. and Wong W.S. "An Expert System
for
the
Detection of Cervical Cancer Cells Using Knowledge-Based Image
Analyser", Artificial
Intelligence in Medicine, 8, pp.67-90, 1996, published by Elsevier
Science.
- 张文修, 徐宗本, 梁怡, 梁广锡 包
含度理论 模糊系统与数学 10 (4), 1-9, 1996
- (Wong M.L.) and Leung K. S., "Genetic Logic Programming
and
Applications"
- IEEE Expert, pp.68-76, Vol.10, No.5, Oct 1995
- Yam Y. and Leung K. S., Future Directions of Fuzzy
Theory
and
Systems, published by World Scientific Publishing as a monograph,
1995.
- Leung K.S. and (So Y.T.), "Consistency Checking for
Fuzzy
Expert
Systems" - International Journal of Approximate Reasoning,
Vol.9,
No.3, pp.263-282, Oct., 1993, North-Holland, U.S.A.
- Leung Y. and Leung K. S., "An Intelligent Expert System
Shell
for
Knowledge-Based Geographic Information Systems: 1, The Tools" - International
Journal of Geographical Information Systems, Taylor & Francis
Ltd,
U.K., Vol.7, No.3, pp.189-199, 1993.
- Leung Y. and Leung K. S., "An Intelligent Expert System
Shell
for
Knowledge-Based Geographic Information Systems: 2, Some Applications" -
International
Journal of Geographical Information Systems, Taylor & Francis
Ltd,
U.K., Vol.7, No.3, pp.201-213, 1993.
- Leung K.S., (Fan Y.) and (Young F.Y.), "A Chinese
Dictionary
System
Based on Fuzzy Logic and Object-Oriented Approach" - Computer
Processing
of Chinese and Oriental Languages - An International Journal of the
Chinese Language Computer Society, World Scientific Publishing, Vol.6,
No.2, pp.205-219, Dec., 1992, Canada.
- K.S. Leung and (M.H. Wong), "Fuzzy Concepts in an Object
Oriented
Expert System Shell", International Journal of Intelligent Systems,
Vol. 7, No. 2, pp. 171-192, published by John Wiley, N.Y., USA, Feb.
1992.
- K.S. Leung and (M.L. Wong), "Automatic Refinement of
Knowledge Bases
with Fuzzy Rules", Knowledge-Based Systems, Vol.4, No.4,
pp.231-246,
Butter worth-Heinemann, Oxford, U.K., Dec. 1991.
- K.S. Leung and (M.L. Wong), "Inducing and Refining
Rule-based Knowledge
from Inexact Examples", Knowledge Acquisition, Vol.3, No.3,
pp.291-315,
Academic Press, London, Sept. 1991.
- Leung K.S. and (Wong M.L.), "AKARS-1: An Automatic
Knowledge
Acquisition
and Refinement System" - Knowledge Acquisition for Knowledge-Based
Systems,
IOS Press, Amsterdam, 1991.
- Wong W.S., Leung K. S. and (So Y.T.), "The Recent
Development
and
Evaluation of A Medical Expert System (ABVAB)" - International
Journal
of Bio-Medical Computing, Vol.25, No.2, pp.223-329, April, 1990.
- (Wong M.H). and Leung K. S., "A Fuzzy Database-Query
Language"
- Information
Systems, Pergamon Press, Vol.15, No.5, pp.583-590, Oct., 1990.
(Fuzzy Query Language)
- K.S. Leung and (M.H. Wong), "An Expert System Shell
Using
Structured
Knowledge : An Object Oriented Approach", IEEE
COMPUTER,
Vol.23, No.3, pp. 38-47, March 1990.
- Leung K.S., (Wong M.H.) and (Lam W.), "A Fuzzy Expert
Database System"
- Data & Knowledge Engineering, North-Holland, Vol.4, No.4,
pp.287-304, Dec., 1989.
- Lee K.H., Leung K. S. and (Cheang S.M.), "A
Microprogrammable
List
Processor for Personal Computers" - IEEE MICRO, Vol.10,
No.4,
pp.50-61, Aug., 1990.
- Leung K.S., Lee K.H. and (Cheang S.M.), "List Processing
for
Artificial
Intelligence Applications" - Microprocessing and Microprogramming -
The Euromicro Journal, Vol.26, No.4, pp.271-287, Dec., 1989.
- K.S. Leung and (W. Lam), "A Fuzzy Expert System Shell
Using
Both
Exact and Inexact Reasoning", Journal of Automated Reasoning,
published
by D. Reidel Publishing Co., Holland, Vol.5, No.2, pp.207-233, June
1989.
- Leung K.S., Wong W.S. and (Lam W.), "Applications of a
Novel
Fuzzy
Expert System Shell" - Expert Systems: The International Journal of
Knowledge Engineering, Vol.6, No.1, pp.2-10, Feb., 1989.
- Leung K.S., Wong W.S. and (Lam W.), "The Development of
an
Expert
Computer System on Medical Consultation" - International Journal of
Bio-Medical Computing, Vol.23, No.3, pp.265-278, Dec., 1988.
- Leung
K.S. and (Lam W.), "Fuzzy Concepts in Expert
Systems"
- IEEE
COMPUTER, Vol.21, No.9, pp.43-56, Sept., 1988.
International Conference & Other Refereed Publications (student)
- Y
Yang, Y Zhang, (S Li), X Zheng, MH Wong, KS Leung, L Cheng. “A robust
and generalizable immune-related signature for sepsis diagnostics”.
IEEE/ACM Transactions on Computational Biology and Bioinformatics; 2021
- P
Liu, X Zheng, MH Wong, KS Leung. “Drug2vec: A Drug Embedding Method
with Drug-Drug Interaction as the Context”. International Conference on
Engineering Applications of Neural Networks, 326-337; 2020
- (S Li), W Chen, Z Wen, KS Leung. “Stochastic online learning with probabilistic graph feedback”. Proceedings of the AAAI 2020 Conference on Artificial Intelligence 34 (04), 4675-4682; 2020
- (Shuai Li), W Chen, S Li, KS Leung. “Improved Algorithm on Online Clustering of Bandits “. Accepted in IJCAI 2019.
- (S
Lai), CH Lo, KS Leung, Y Leung. “CUHK at MRP 2019: Transition-Based
Parser with Cross-Framework Variable-Arity Resolve Action”. Proceedings
of the Shared Task on Cross-Framework Meaning Representation; 2019; https://www.aclweb.org/anthology/K19-2010.pdf
- (PK
Wong), ML Wong, KS Leung. “Probabilistic grammar-based deep
neuroevolution”. Proceedings of the Genetic and Evolutionary
Computation Conference Companion; 2019; https://doi.org/10.1145/3319619.3326778
- (PK
Wong), ML Wong, KS Leung. “ Semantic fitness function in genetic
programming based on semantics flow analysis”. Proceedings of the
Genetic and Evolutionary Computation Conference Companion; 2019; https://doi.org/10.1145/3319619.332196
- (R Wang), (S Li), MH Wong, KS Leung. "Drug-Protein-Disease
Association Prediction and Drug Repositioning Based on Tensor
Decomposition". 2018 IEEE International Conference on Bioinformatics
and Biomedicine (BIBM'18); 305-312; 2018.
- WC Wong, (S Lai), W Lam, KS Leung. "Guiding Approximate Text Classification Rules via Context Information". Asia Information Retrieval Symposium, 133-139; 2018.
- (P Liu), KS Leung. "Accelerating
Drug Discovery Using Convolution Neural Network Based Active
Learning".TENCON 2018-2018 IEEE Region 10 Conference, 2005-2010; 2018.
- (S Lai), KS Leung, Y Leung. "SUNNYNLP
at SemEval-2018 Task 10: A Support-Vector-Machine-Based Method for
Detecting Semantic Difference using Taxonomy and Word Embedding
Features". Proceedings of The 12th International Workshop on Semantic
Evaluation, 741-746; 1; 2018.
- (PK Wong), ML Wong, KS Leung. Long-Short Term Memory Network for RNA
Structure Profiling Super-Resolution. International Conference on Theory and
Practice of Natural Computing, 255-266; 2017
- (KK
Tong), KS Leung, Y Leung. “A system for personalized health care with
ECG and EEG signals for analysis”. International Smart Cities
Conference (ISC2), 1-6; 2017
- (PK Wong), ML Wong, KS Leung. Learning grammar rules in
probabilistic Grammar-based Genetic Programming. International Conference on
Theory and Practice of Natural Computing, 208-220; 2016
- (WY Yi), KS Leung, Y Leung, ML Meng, T Mak. Modular
sensor system (MSS) for urban air pollution monitoring. SENSORS, 2016 IEEE,
1-3; 2016
- (MC Yuen), I King, KS Leung. An Online-Updating Approach
on Task Recommendation in Crowdsourcing Systems. International Conference on
Neural Information Processing, 91-101; 2016
- (PK Wong), ML Wong, KS Leung. Hierarchical Knowledge in
Self-Improving Grammar-Based Genetic Programming. International Conference on
Parallel Problem Solving from Nature, 270-280; 2016
- E.S Annie Lee,( HY Sze-To), MH Wong, KS Leung, Terrence CK Lau,
Andrew K. C. Wong, “Discovering Protein-DNA Binding Cores by Aligned
Pattern Clustering”. 2014 IEEE International Conference on
Bioinformatics and Biomedicine ( BIBM'14),
pp.125-130, Nov, 2014.
- (PK Wong), (LY Lo), ML Wong, KS Leung, “Grammar-based genetic
programming with dependence learning and Bayesian network classifier”.
Proceedings of the 2014 conference on Genetic and evolutionary
computation, GECCO 2014,
pp.959-966, ACM.
- (PY Wong), TM Chan, MH Wong, KS Leung,"Predicting Approximate
Protein-DNA Binding Cores Using Association Rule Mining" ICDE 2012 (International Conference
on Data Engineering), Washinton DC, USA, 2012.04.01 (pp.965-976 )
- (PY Wong), TM Chan,
MH Wong and KS Leung, Efficient
Algorithm for Mining Correlated Protein-DNA Binding Cores, In
Proceedings of the DASFAA 2012, pp. 470-481.
- (Hongjian Li), KS Leung, MH
Wong: idock: A multithreaded virtual screening
tool
for flexible ligand docking. CIBCB
2012: 77-84
- (CM Tse), (Hongjian Li), KS
Leung, KH Lee, MH Wong: Interactive Drug Design in
Virtual Reality. IV
2011: 226-231
- (Hongjian Li), (B Ni), MH Wong,
KS Leung: A fast CUDA implementation of agrep
algorithm for approximate nucleotide sequence matching. SASP
2011: 74-77
- (B Ni), (LY Lo), KS Leung,
“A generalized sequence pattern matching algorithm using complementary
dual-seeding”. IEEE International Conference on Bioinformatics &
Biomedicine (BIBM 2010),
pp.369-372.
- TM Chan, KH Lee, KS
Leung, Pietro Lio', Generic Spaced DNA Motif Discovery Using Genetic
Algorithm. In Proceedings of the 2010 IEEE Congress on Evolutionary
Computation (CEC 2010), pp. 2647-2654.
- (LY Lo), (TM Chan),
KH Lee, KS Leung, Challenges Rising from Learning Motif Evaluation
Functions Using Genetic Programming. In GECCO 10: Proceedings of
the 2010 conference on Genetic and evolutionary computation, pp.
171-178.
- (G Li), (TM Chan),
KS Leung and KH Lee, An Estimation of Distribution Algorithm for Motif
Discovery. In Proceedings of the 2008 IEEE Congress on Evolutionary
Computation (CEC 2008), IEEE Press, 2008, pp. 2416-2423.
- (TM Chan), KS
Leung, KH Lee, TFBS identification by position- and consensus-led
genetic algorithm with local filtering. In GECCO 07: Proceedings of
the 2007 conference on Genetic and evolutionary computation, pp.
377-384.
- (Wenye Li), K. S. Leung and K. H. Lee, Large-scale RLSC Learning
Without Agony, Proceedings of the 24th International Conference on
Machine Learning (ICML 2007),
pp. 529-536, Corvallis, Oregon, USA, 20-24 June 2007.
- (Wenye Li), K. S. Leung and K. H. Lee, Generalizing the Bias Term
of Support Vector Machines, Proceedings of the 12th International Joint
Conference on Artificial Intelligence (IJCAI07)
(Volume one), pp. 919 – 924, Hyderabad, India, 6-12 January 2007.
- (Wenye Li), K. H. Lee and K. S. Leung, Generalized Regularized
Least-Squares Learning with Predefined Features in a Hilbert Space,
Proceedings of the 12th Annual Conference on Neural Information
Processing Systems (NIPS2006),
5-7 December, 2006, Vancouver, Canada, pp 881-888.
- KS Leung,YT Ng, KH Lee, LY Chan, KW Tsui, Tony Mok, CH Tse,
Joseph Sung, "Data Mining on DNA Sequences of Hepatitis B Virus by
Nonlinear Integrals" Proceedings Taiwan-Japan Symposium on Fuzzy
Systems & Innovational Computing, 3rd meeting, pp.1-10 Aug 2006,
Japan (Keynote Speech)
- (Y. Liang), K. S. Leung and Tony S. K. Mok, Automating the Drug
Scheduling with Different Toxicity Metabolism in Cancer Chemotherapy
via Evolutionary Computation, Lecture Notes in Computer Science
(GECCO2006: ACM International Conference on Genetic and Evolutionary
Computation Conference), Seattle, WA, USA, July 2006, (nomination for best paper award)
- (W.H. Shum), K.S. Leung, and M.L. Wong, "Learning Functional
Dependency Networks based on Genetic Programming" ICDM'05, the
proceedings The Fifth IEEE International Conference on Data Mining (ICDM),
pp.394-401, New Orleans, Louisiana, U.S.A., November 27-30, 2005, the
IEEE Computer Society Press. (full paper, acceptance rate: 10.95%)
- (W.S. Lau), (Gang Li), K.H. Lee, K.S. Leung and Sin Man Cheang,
“Multi-logic-Unit Processor: A Combinational Logic Circuit Evaluation
Engine for Genetic Parallel Programming”, Proceedings of EuroGP 2005:
167-177, 2005
- (LIANG Yong), Leung K.S. and Mok Tony.
"Evolutionary Drug Scheduling Model for Cancer Chemotherapy."
Proceedings of Genetic and Evolutionary Computation Conference (Part I)
- GECCO 2004, (also as Lecture Notes in Computer Science LNCS
3102), pp. 1126-1137, Germany, (Nomination
for best paper award at
International Conference GECCO-2004. ) 2004.06.
- (Cheang S. M.), Lee K.H. and Leung K. S. "Designing Optimal
Combinational Digital Circuits Using a Multiple Logic Unit Processor."
Proceedings of the 7th European Conference (EuroGP 2004) (also in
Lecture Notes in Computer Science Vol 3003) "Maarten
Keijzer, Una-May O'Reilly, Simon M. Lucas, Ernesto Costa, Terence Soule
(Eds.)" Springer-Verlag Berlin Heidelberg, 23-34,
Germany, 2004.04
- (H.D. Jin), K.S. Leung and M.L. Wong, “Scalable Model-Based
Clustering by Working on Data Summaries,” The IEEE Int. Conf. on Data
Mining- (ICDM 2003, , Regular paper, acceptance rate 11.6%),
pp.91-98, USA, Nov 2003
- K.S.Leung & (Y.Liang) "Adaptive
Elitist-population Based Genetic Algorithm for Multimodal Function
Optimization,"
Proceeding of International Conference GECCO-2003, pp.1160-1171, July
2003 ( Nomination for best paper
award at International Conference
GECCO-2003.)
- Leung K.S. and (Liang Y.) “Evolution Strategies with a Fourier
Series Auxiliary Function for Difficult Function Optimization” .”
Proceedings of The 4th Int. Conf. On Intelligent Data Engineering and
Automated Learning- IDEAL 2003, pp.303-312, March 2003, LNCS 2690.
(regular paper, 29% acceptance rate)
- (Shum W.H.), (Jin H.D.), Leung, K.S. and Wong, M.L. (2002). “A
Self-Organizing Map with Expanding Force for Data Clustering and
Visulization.” Proceedings of the 2002 International Conference on Data
Mining (ICDM), pp434-441,
Japan. (regular paper, 19.6% acceptance rate)
- Wong, M.L., (Lee, S.Y.), and Leung, K.S. (2002). “A Hybrid
Approach to Discover Bayesian Networks from Databases Using
Evolutionary Programming.” Proceedings of the 2002 International
Conference on Data Mining (ICDM),
pp498-505, Japan. (regular paper,
19.6% acceptance rate)
- K.S. Leung, K.H. Lee, and (S.M. Cheang),"Genetic Parallel
Programming -
Evolving Linear Machine Codes on a Multi-ALU Processor," The Int. Conf.
on Artificial Intelligence in Engineering and Technology ICAIET-2002,
Sabah,
Malaysia, 17-18 June 2002.
- (Liang Y.), Leung K.S., "Two-way Mutation Evolution
Strategies,"
2002 Congress on Evolutionary Computation (CEC'02) (accepted).
- (Z.Y Zhu) & K.S. Leung, "Asynchronous Self-Adjustable Island
Genetic
Algorithm for Multi-Objective Optimization Problems," 2002 Congress on
Evolutionary Computation (CEC'02), May 12-17, 2002, USA.
(Accepted)
- (Z.Y. Zhu) & K.S. Leung, "An Enhanced Annealing Genetic
Algorithm
for
Multi-Objective Optimization Problems," Genetic and Evolutionary
Computation
Conference 2002 (GECCO-2002), July 9-13,2002, NY, USA.
- Wong, M.L., (Lee, S.Y.), and Leung, K.S. (2002). "A Hybrid Data
Mining
Approach to Discover Bayesian Networks Using Evolutionary
Programming."
Proceedings of the 2002 Genetic and Evolutionary Computation
Conference.
(Accepted)
- Wong, M. L., (Lee, S. Y.), and Leung, K. S. (2002). A Hybrid
Approach
to
Learn Bayesian Networks Using Evolutionary Programming. Proceedings of
2002 Congress on Evolutionary Computation.
- K.S. Leung, K.H. Lee, and (S.M. Cheang), "Balancing Samples'
Contributions
on GA Learning," The Int. Conf. on Evolvable Systems: From Biology to
Hardware,
ICES2001, Tokyo, Japan, 3-5 October 2001.
- (Zhu Z.Y.) and Leung K.S. "Non-dominated Sorting Annealing
Genetic
Algorithms
for Multi-objective Optimization Problems," Proceedings of the
International
Conference on Computational Intelligence, Robotics & Autonomous
systems,(CIRAS
2001), pp.1-6, 28-30 Nov. 2001, Singapore.
- (Jin Huidong), Leung Kwong Sak, Wong Man Leung, " Genetic-guided
Model-based
Clustering Algorithms," Proceedings of the International Conference on
Artificial Intelligence (IC-AI'2001) Vol. II, pp.653-659 CSREA Press,
25-28
July, 2001
- (Liang Y.), Leung K.S. and Xu Z.B., "Fast-GA: A Genetic Algorithm
with
Exclusion-based Selections" Proceedings of 2001 WSES
International
Conference on: Evolutionary Computations (EC'01), pp.638(1)-638(6),
Spain.
Also appears as a book chapter in Advances in Fuzzy Systems &
Evolutionary
Computation, (Ed. N. Mastorakis), pp.311-316, Feb 2001.
- (Yue H.Y.), King I. and Leung K.S., "Fuzzy Clustering Method for
Content-based
Indexing" Proceedings of International Conference on Fuzzy Sets and
Fuzzy
Systems (FSFS '01), pp.541(1)-(6), Spain. Also appears as a book
chapter in Advances in Fuzzy Systems & Evolutionary Computation,
(Ed.
N. Mastorakis), pp.138-143, Feb 2001.
- (JIN H.D.), Leung K.S. and Wong M.L., "An Integrated
Self-Organizing
Map
for the Travelling Salesman Problem" Proceedings of International
Conference on: Neural Networks and Applications (NNA '01),
pp.428(1)-(6).
Also appears as a book chapter in Advances in Neural Networks and
Applications,
(Ed. N. Mastorakis), pp.235-240, Feb 2001.
- (Zhu Z.Y.) and Leung K. S., "Exclusion-based Cooperative
Coevolution
Genetic
Algorithm" 2001 WSES International Conference on Evolutionary
Computations
(EC'01) pp.637(1)-637(6), 2.2001.
- (JIN H.D.), Leung K.S. and Wong M.L., "An Integrated
Self-Organizing
Map
for the Traveling Salesman Problem" International Conference on:
Neural Networks and Applications (NNA '01)), pp.428(1)-(6). Also
appears
as a book chapter in Advances in Neural Networks and Applications, (Ed.
N. Mastorakis), pp.235-240, Feb 2001.
- (Jin H.D), Leung K.S., Wong M.L., "A Genetic Algorithm-Guided
Model-based
Clustering Algorithm" In Proceedings of 2000 Genetic & Evolutionary
Computation Conference (Late breaking papers), pp.133-140, U.S.A.,
July,
2000.
- Leung K.S., Wong M.L., and W. Lam and Jack Cheng. "Applying
Evolutionary
Computation to Discover Knowledge from Medical Databases" (Invited
paper),
International Workshop on Evolutionary Computation, April 2000,
Wuhan,
China.
- (Jin H.D), Leung K.S., Wong M.L., "Designing an Expanded SOM for
Travailing
Salesman Problem by Genetic Algorithms " In Proceedings of 2000 Genetic
& Evolutionary Computation Conference, pp.1097, U.S.A., July, 2000.
- (Y.C. Wong), K.S. Leung, and C.K. Wong, "Computation of
Physical
Properties of Materials using Percolation Networks" In
Proceedings
of the IASTED International Conference on Artificial Intelligence and
Soft
Computing, pp.33-37, U.S.A., Aug. 1999.
- (C.W.Ho), K.H.Lee, and K.S.Leung "A Genetic Algorithm Based on
Mutation
and Crossover with Adaptive Probabilities," Proceedings of 1999
Congress
on Evolutionary Computation, pp.768-775. IEEE, U.S.A., July 1999.
- (Lee Y.W.), Leung K.S. and M Satyanarayanan
"Operation-based
Update
Propagation in a Mobile File System" Proceedings of 1999 USENIX
Annual
Technical Conference, pp.43-56, U.S.A., June 1999.
- (Yuk-Yin Wong), Kin-Hong Lee, Kwong-Sak Leung. "A Stochastic
Load
Balancing Algorithm for Internet Computing Environment".
Proceedings
of The International Conference on Parallel and Distributed
Processing
Techniques and Applications (PDPTA'99), Vol. V, pp.2587-2593,
CSREA
Press, Las Vegas, Nevada, USA, 1999.06.28
- Leung K.S., Wong T. and King I. "Probabilistic
Cooperative-Competitive
Hierarchical Modeling for Global Optimization" Proceedings of the 5th
International
Conference on Soft Computing and Information/Intelligent Systems,
pp.748-751,
Oct, 1998.
- Leung K.S., Wong T. and King I. "Probabilistic
Cooperative-Competitive
Hierarchical Modeling as a Genetic Operator in Global Optimization"
Proceedings
of IEEE International Conference on Systems, Man, and Cybernetic
pp.3959-3964,
Oct, 1998. (IF: 7.384)
- Ngan P. S.,. Wong M. L, Leung K. S. and Cheng J. C. Y. "Using
Grammar
Based
Genetic Programming for Data Mining of Medical Knowledge." Genetic
Programming
1998: Proceedings of the Third Annual Conference, pp.254-259, USA, July
1998.
- Lam W., Wong M. L., Leung K. S. and Ngan P. S.. "Discovering
Probabilistic
Knowledge from Databases Using Evolutionary Computation and Minimum
Description
Length Principle." Genetic Programming 1998: Proceedings of the Third
Annual
Conference, pp.786-794, USA, July 1998.
- Leung K.S. and Zhenyuan Wang, A new nonlinear integral used for
information
fusion, Proc. WCCI'98 (1998 IEEE World Congress on Computational
Intelligence),
802-807., USA.
- Leung, K. S., Wong, M. L., Lam, W., and Wang, Z. Y.. Discovering
Nonlinear
Integral Networks from Databases Using Evolutionary Computation and
Minimum
Description Length Principle. Proceedings of IEEE International
Conference
on Systems, Man, and Cybernetic pp.2326-2331, Oct 1998.
- (S. K. Cheung), K. S. Leung, A. Albrecht, and C. K. Wong,
``Optimal
placements
of flexible objects: An adaptive simulated annealing approach,'' in
Proceedings
of the Fifth International Conference on Parallel Problem Solving From
Nature (PPSN V) , pp.968-977, Sept 1998.
- Wang Z.Y., Leung K.S. and Wang J. "Genetic Algorithms Used for
Determining
Belief Measures and Plausibility Measures," Annual Meeting of the North
American Fuzzy Information Processing Society (NAFIPS'97), pp.195-198,
New York, U.S.A., IEEE, September 1997.
- (Cheung S.K.), Leung K.S., Albrecht A. and Wong C.K.
"Optimal
Placements
of Flexible Objects: An Evolutionary Programming Approach" -
Proceedings
of the Seventh International Conference on Genetic Algorithms, Michigan
State University, (ICGA97), pp. 583—590, 1997.
- Wang Z.Y., Leung K.S. and Wang J. "Genetic algorithms used for
Determining
Nonadditive Set Functions in Information Fusion" - Proceedings of
Seventh
International Fuzzy Systems Association world Congress, pp.518-521,
Academia,
Prague, June 1997.
- Leung K. S., Lee K.H. and (Lau C.K.) "A Fuzzy-Logic
Multimedia Chinese
Dictionary Shell" In the Proceedings of the 20th Anniversary
Conference
on Computer Processing of Oriental Languages, U.S.A., pp.239-246,
November,
1995.
- (Ji H. B.), Leung K. S. and Leung Y. "Gaussian
Correlation
Associative
Memory" In the Proceedings of the 1995 IEEE International
Conference
on Neural Networks. pp.1761-1766, December, 1995.
- (Wong, M. L.) and Leung, K. S. (1995). "Combining Genetic
Programming
and Inductive Logic Programming using Logic Grammars." In the
Proceedings
of the 1995 IEEE International Conference on Evolutionary Computing,
Vol.2, pp.733-736, Dec., 1995.
- (Wong, M. L.) and Leung, K. S. (1995). "Applying Logic
Grammars
to Induce sub- functions in Genetic Programming." In the Proceedings of
the 1995 IEEE International Conference on Evolutionary Computing,
Vol.2, pp.737- 740, Dec., 1995.
- (Wong, M. L.) and Leung, K. S., "An Adaptive Inductive
Logic
Programming
System using Genetic Programming." In Proceedings of the Fourth
Annual
Conference on Evolutionary Programming, San Diego, USA, pp.737-752,
MA:MIT Press. March, 1995.
- (Tang Y.C. Anthony) and Leung K. S., "A Modified Edge
Recombination
Operator for the Travelling Salesman Problem" - Lecture Notes
in
Computer
Science, 866, pp.180-188, Parallel Problem Solving from Nature
- PPSN III, the International Conference on Evolutionary
Computation,
Jeruselum, Israel, Oct 1994.
- (Wong, M. L.) and Leung, K. S., "Learning First-order
Relations
from Noisy Databases using Genetic Algorithms." In Proceedings of the Second
Singapore International Conference on Intelligent Systems,
pp.B159-164,
Nov. 1994.
- Leung K.S., Ji H.B. and Leung Y., "Weighted
Outer-Product
Learning
Associative Memory with Adaptive Algorithms" - Proceedings of the IASTED
International Conference on Artificial Intelligence, Expert Systems and
Neural Networks, pp.100-105, Zurich, Switzerland, July 1994.
- Leung K.S. and Leung Y., "Fuzzy Knowledge-Based Systems:
Reviews
and Perspectives" - Workshop on the Future Directions of Fuzzy
Theory
and Systems, pp.A.1-16, Oct.,1993.
- Leung K.S., Leung Y., (So L.) and (Yam K.F.), "Rule
Learning
in
Expert Systems Using Genetic Algorithm: 1, Concepts" - Proceedings
of
the 2nd
International Conference on Fuzzy Logic & Neural Networks, Japan,
July 17-22, 1992, pp201-204.
- Leung K.S., Leung Y., (So L.) and (Yam K.F.), "Rule
Learning
in
Expert Systems Using Genetic Algorithm: 2, Empirical Studies" -
Proceedings
of the 2nd International Conference on Fuzzy Logic & Neural
Networks,
Japan, July 17-22, 1992, pp205-208.
Research
summary (KS Leung)
Research
Group:
We have a small research group
containing
myself, Prof KH Lee, Prof MH Wong and some 8
research students, and collaborators from Department of
Biochemistry
(Prof. Stephen Tsui), Department of Medicine & Therapeutic (Profs.
Joseph
Sung and Prof. Henry LY Chan), and Department of Clinical Oncology
(Prof Tony
Mok);
Prof. Hsiang-Fu KUNG, Stanley Ho Centre for Emerging Infectious Diseases
Prof. Marie Chia-Mi LIN, Department of Surgery, Prince of Wales Hospital
Prof. Pang-Chui SHAW, School of Biomedical Sciences
Research Fields: Evolutionary Computation, Data
mining, and
Bioinformatics
Representative Projects and Results:
(1)
Finding DNA
Markers of Hepatitis B Virus (HBV)
- Supported
by an ITF grant of over $4.4 million+ 2 million from drug industry and
several
other small grants
- Cross
departmental project and top international collaborators
- Largest
project of its type
- Impact:
Over 20% and 10% of Mainland and Hong Kong Populations are carriers and
many
will turn into lever cancer. About 1 million people died of related
diseases worldwide each year.
-
Results:
We found some significant markers which can be used to diagnosis
potential lever
cancers caused by Hepatitis B with around 80% accuracy. Patents have been obtained through RTAO. A new approach
based on
Information Gain, non-linear integral and rule learning algorithms have
been
adapted to achieve this. New subtypes of HBV were also
discovered.
Publications
(some more in the pipeline):
- KS Leung, KH Lee, (JF
Wang), (Eddie
YT Ng), Henry LY Chan, Stephen KW Tsui, Tony SK Mok, C.H. Tse,
Joseph JY
Sung, “Data
Mining on DNA Sequences
of Hepatitis B Virus”. IEEE/ACM Transactions on
Computational Biology and Bioinformatics. vol.8
no.2, pp.428-40. 2011.03.
- KS
Leung,YT Ng, KH Lee, LY Chan, KW Tsui, Tony Mok, CH Tse, Joseph Sung,
"Data Mining on DNA Sequences of Hepatitis B Virus by Nonlinear
Integrals" Proceedings Taiwan-Japan Symposium on Fuzzy Systems &
Innovational Computing, 3rd meeting, pp.1-10 Aug 2006, Japan (Keynote
Speech)
- Joseph JY Sung, KW Tsui, CH Tse, Eddie
YT Ng, KS Leung, KH Lee, Tony SK Mok, A. Bartholomeusz, CC Au, S
Locarnini, Henry LY Chan “Genotype-Specific Genomic Markers Associated
with Primary Hepatoma Based on Complete Genomic Sequencing of Hepatitis
B Virus,” The Journal of Virology,
Vol.82, No.7, pp3604-3611, Apr. 2008. (IF 5.341).
- Chan HLY, Tsui SKW, Tse CH, Ng EYT, Au TCC,
Yuen L,
Bartholomeusz A, Leung KS, Lee KH, Locarnini S, Sung JJY.
Epidemiological and virological characteristics of two subgroups of
genotype C hepatitis C virus. J Infect Dis 2005;191:2022-32. (impact
factor: 4.943)
- Sung JJY, Tsui SKW, Tse CH, Ng
E, Leung KS, Lee KH, Mok TSK,
Bartholomeusz A, Chan HLY. Viral genomic marker associated with the
development
of hepatocellular carcinoma: A complete genomic sequence of hepatitis B
virus.
Gastroenterology 2005;128:A743. (Impact factor: 13.092)(abstract)
-
Henry L.Y. Chan, C.H. Tse, Eddie Y.T. Ng, K.S. Leung , K.H. Lee, K.W. Tsui , Joseph J. Y. Sung “Phylogenetic,
Virological and Clinical
Characteristics of Genotype C Hepatitis B Virus
With Tcc At Codon 15 Of The Precore Region,” Journal of
Clinical Microbiology, (impact factor 3.439) accepted
- ****DNA Patents****
- SUNG
Joseph Jao Yiu; CHAN Lik Yuen Henry; TSUI Kwok Wing; LEUNG Kwong Sak;
MOK Shu
Kam Tony; BARTHOLOMEUSZ Angeline; LEUNG Wai Yee Nancy and LEE Kin
Hong. "Genomic Markers of Hepatitis B Virus in
Hepatocellular
Carcinoma". United States Patent no.
US7439020B2. U.S.A, 2008.10.21.
- SUNG
Jao Yiu, Joseph; CHAN Lik Yuen, Henry; TSUI Kwok Wing, Stephen; LEUNG
Kwong
Sak; MOK Shu Kam, Tony; BARTHOLOMEUSZ Angeline; LEUNG Wai Yee, Nancy
and LEE
Kin Hong. "Genomic Markers of Hepatitis B Virus Associated with
Hepatocellular Carcinoma." United States
Patent no.
US7871780. U.S.A, 2011.01.18.
- SUNG
Joseph Jao Yiu; CHAN Lik Yuen Henry; TSUI Kwok Wing; LEUNG Kwong Sak;
MOK Shu
Kam Tony; BARTHOLOMEUSZ Angeli; LEUNG Wai Yee Nancy and LEE Kin Hong. "與肝細胞癌相關的乙型肝炎病毒基因組標志物".
Chinese Patent
no. ZL200510098674.0. China,
2008.03.26.
- SUNG
Joseph Jao Yiu; CHAN Lik Yuen Henry; TSUI Kwok Wing; LEUNG Kwong Sak;
MOK Shu
Kam Tony; BARTHOLOMEUSZ Angeline; LEUNG Wai Yee Nancy and LEE Kin Hong. "Genomic Markers of Hepatitis B Virus in
Hepatocellular Carcinoma 與肝細胞癌相關的乙型肝炎病毒基因組標志物".
HK
Standard Patent no. HK1087440. Hong Kong
SAR, 2008.06.13.
- SUNG
Joseph Jao Yiu; CHAN Lik Yuen Henry; TSUI Kwok Wing; LEUNG Kwong Sak;
MOK Shu
Kam Tony; BARTHOLOMEUSZ Angeli; LEUNG Wai Yee Nancy and LEE Kin Hong. "與肝細胞癌相關的乙型肝炎病毒基因組標志物".
Chinese Patent
no. ZL200810004158.0. China,
2010.12.15.
- SUNG
Joseph Jao Yiu; CHAN Lik Yuen Henry; TSUI Kwok Wing; LEUNG Kwong Sak;
MOK Shu
Kam Tony; BARTHOLOMEUSZ Angeline; LEUNG Wai Yee Nancy and LEE Kin Hong. "Genomic Markers of Hepatitis B Virus in
Hepatocellular Carcinoma 與肝細胞癌相關的乙型肝炎病毒基因組標志物".
HK
Standard Patent no. HK1120569. Hong Kong
SAR, 13 May 2011.
- SUNG
Joseph Jao Yiu; CHAN Lik Yuen Henry; TSUI Kwok Wing; LEUNG Kwong Sak;
MOK Shu
Kam Tony; BARTHOLOMEUSZ Angeli; LEUNG Wai Yee Nancy and LEE Kin Hong. "與肝細胞癌相關的乙型肝炎病毒基因組標志物".
Chinese Patent
no. ZL200810004159.5. China, 7 September
2011.
- SUNG
Joseph Jao Yiu; CHAN Lik Yuen Henry; TSUI Kwok Wing; LEUNG Kwong Sak;
MOK Shu
Kam Tony; BARTHOLOMEUSZ Angeline; LEUNG Wai Yee Nancy and LEE Kin Hong. "Genomic Markers of Hepatitis B Virus in
Hepatocellular Carcinoma 與肝細胞癌相關的乙型肝炎病毒基因組標志物".
HK
Standard Patent no. HK1120570. Hong Kong
SAR, 3 February 2012.
- SUNG
Joseph Jao Yiu; CHAN Lik Yuen Henry; TSUI Kwok Wing; LEUNG Kwong Sak;
MOK Shu
Kam Tony; BARTHOLOMEUSZ Angeli; LEUNG Wai Yee Nancy and LEE Kin Hong. "與肝細胞癌相關的乙型肝炎病毒基因組標志物".
Chinese Patent
no. ZL200810004160.8. China, 8 December 2010.
- SUNG
Joseph Jao Yiu; CHAN Lik Yuen Henry; TSUI Kwok Wing; LEUNG Kwong Sak;
MOK Shu
Kam Tony; BARTHOLOMEUSZ Angeline; LEUNG Wai Yee Nancy and LEE Kin Hong. "Genomic Markers of Hepatitis B Virus in
Hepatocellular Carcinoma 與肝細胞癌相關的乙型肝炎病毒基因組標志物".
HK
Standard Patent no. HK1120571. Hong Kong
SAR, 13 May 2011.
- SUNG
Jao Yiu, Joseph; CHAN Lik Yuen, Henry; TSUI Kwok Wing, Stephen; LEUNG
Kwong
Sak; MOK Shu Kam, Tony; BARTHOLOMEUSZ Angeline; LEUNG Wai Yee, Nancy
and LEE
Kin Hong. "Genomic Markers of Hepatitis B Virus Associated with
Hepatocellular Carcinoma." World Intellectual Property Organization.
Publication number WO/2006/026931. 2006.03.16
(2)
Dynamic
Cancer Drug Scheduling (in time
sequences) for Chemotherapy
- We have created a
multi-mode (solutions), multi-drug optimizer for Cancer Chemotherapy,
so that
the Oncologist (Dr Mok) can have a choice of several (sub-)optimal
solutions to
consider for the patients. The approach is based on a new memetic
Evolutionary
Algorithm working on a set of dynamic differential equations modelling
the drug
responses.
- Support by a RGC
Earmarked Grant
- (S. M.
Tse), Y. Liang, K. S. Leung, K. H. Lee
and Tony S. K. Mok, A Memetic Algorithm for Multiple Drugs Cancer
Chemotherapy Schedule Optimization, IEEE
Transactions on Systems, Man
and Cybernetics - Part B, vol. 37, no. 1, pp.84-91, Feb. 2007.
- (Liang Y.), Leung K.S. and Tony Mok S.K.. "A
Novel Evolutionary Drug Scheduling Model in Cancer Chemotherapy," IEEE
Transactions on Information
Technology in
Biomedicine, Vol.10, No.2, pp.237-245, April, 2006.
- (Sui
Man Tse), Yong Liang, K. S. Leung, K. H. Lee and
Tony Mok, “Multiple Drugs Cancer Chemotherapy Scheduling by a New
Memetic
Optimization Algorithm”, Proceedings of the 2005 IEEE Congress on
Evolutionary
Computation .
(3) Motif Discovery
and Gene Network Learning
- We have created a GA with combined representation of position and
concensus led algorithms. The realties on TFBS identification are
encouraging. We are now working on Gene Network Learning based on
this new approach.
- We managed to discover TF-TFBS binding core rules based only on
TRANSFAC data without using 3D infomration. This can help finding
targeted drugs and personal medicine
- T.M. Chan, K.S. Leung, K.H. Lee, M.H.
Wong 1, C.K. Lau , Stephen K.W. Tsui,
Subtypes
of Associated Protein-DNA (Transcription Factor-Transcription Factor
Binding Site) Patterns,
Nucleic Acids Research,
August 2012; doi: 10.1093/nar/gks749
-PY Wong, TM Chan, MH Wong, KS
Leung,"Predicting Approximate Protein-DNA Binding Cores Using
Association Rule Mining" ICDE 2012 (International Conference on Data
Engineering) (accepted)
- (Chan, T.M.), Leung, K.S., and Lee, K.H.,"Memetic Algorithms for
de novo Motif Discovery"
IEEE Transactions on Evolutionary
Computation, 2011.(accepted)
-
T.M. Chan, K.C. Wong, K.H. Lee, M.H.
Wong, C.K. Lau, Stephen K.W. Tsui, K.S. Leung, Discovering approximate-associated sequence
patterns for protein-DNA interactions. Bioinformatics, 2011, 27(4), pp. 471-478.
- Leung, KS, (Wong, KC), (Chan, TM),
Wong, MH, Lee, KH, Lau, CK,
and
Tsui, Stephen, "
Discovering
Protein-DNA Binding Sequence Patterns Using
Association Rule Mining,"
Nucleic
Acids Research. , pp.1-14, 6.2010, doi: 10.1093/nar/gkq500.
- (Chan T.M.), (G. Li), K.S. Leung and
K.H.Lee,
Discovering
multiple realistic TFBS motifs based on a generalized model, BMC
Bioinformatics, 2009, 10:321
- (Chan, T.M.), Leung, K.S., and Lee,
K.H., “TFBS Identification Based on
Genetic Algorithm with Combined Representations and Adaptive
Post-processing,”
Bioinformatics, Vol.24, No.3, pp341-349, Oxford Journals, Feb
2008
- (G. Li), (T.M. Chan), K.S. Leung and K.H.Lee,
A
Cluster Refinement Algorithm for Motif Discovery,
IEEE/ACM Transaction on
Computational Biology and Bioinformatics (accepted)
- (Chan, T.M)., Leung, K.-S., and Lee, K.-H., "TFBS identification by
position- and consensus-led genetic algorithm with local filtering,"
Proceedings of the 9th annual conference on Genetic and evolutionary
computation, London, England, 7-11 July 2007, (GECCO 07), pp.
377–384.
- (LY Lo), ML Wong, KH Lee, KS Leung "High-order dynamic Bayesian
Network learning with hidden common causes for causal gene regulatory
network".
BMC Boinformatics 16
(1), 1
- (LY Lo), ML Wong, KH Lee, KS Leung. "Time Delayed Causal Gene
Regulatory Network Inference with Hidden Common Causes".
PloS ONE, 2015, 10 (9), e0138596
- (Peter LY Lo), KS Leung and
KH Lee, "Inferring Time-Delayed Causal Gene Network using Time-series
Expression Data ",
IEEE/ACM
Transaction on
Computational Biology and Bioinformatics, 2015.Vol. 12, Issue 1,142-154
(4) Computer-aided
drug discovery and protein-ligand docking
- We have discovered several cancer drugs through drug repurposing.
- We have developed idock (https://Github.com/HongjianLi/idock
), a multithreaded virtual screening tool for flexible ligand docking.
It outperforms AutoDock Vina by at least 8.69 times and at most 37.51
times in terms of docking speed.
- We have also developed istar
(http://istar.cse.cuhk.edu.hk
), a SaaS (Software-as-a-Service) platform for idock, igrep and other
programs. Users can submit jobs on the fly at our web site without
software installation.
- We are currently working on GPU acceleration and ligand synthesis.
- Collaborating with Professor Hsiang-Fu KUNG's research group, we
are
laboratory testing a newly discoveried peptide based vaccin for Hand,
Foot and Mouth disease with promising results.
- Applying patent: US
Provisional Application No. 61/863,172 filed on 7 August 2013
Title: Human Enterovirus 71
(EV71) Peptide
***Drug Patents***
- YF Liu, Lin Li, HJ Li, LH Gao, H Lin, X Liu, KS Leung, MH
Wong, Marie CM Lin, and Hsiang-Fu Kung.: “Application of olsalazine
sodium as a medicine for preventing and treating hyperuricemia and
gout.” Patent ID: ZL201610939874.2. Authorization announcement ID:
CN106344591B; 7 Sep 2018.
- XN Shi, Hsiang-fu Kung, KS Leung, HJ
Li, MH Wong, Marie CM Lin, X Liu and D Lu “New application of
vanoxerine dihydrochloride drug. Inventors:. Patent ID:
ZL201510905924.0. Authorization announcement ID: CN105434438B. 17 Sep
2019.
- XN Shi, Hsiang-fu Kung, HJ Li, KS Leung, MH Wong,
Marie CM Lin, X Liu, KB Ke, D Lu and Y Zhu. “Novel application of
aminoquinol.” Patent ID: ZL201610059333.0. Authorization announcement
ID: CN105640955B. 24 Dec 2019.
- XN Shi, Hsiang-fu Kung, HJ
Li, KS Leung, Man-Hon Wong, Marie Chia-mi Lin, Xu Liu and Di Lu “New
application of rafoxanide”. Inventors:. Application ID: 201610059096.8.
Application date: 28 Jan 2016. Publication ID: CN105687171A.
Publication date: 22 Jun 2016. (under review)
- HJ Li, KS Leung, MH Wong and PJ
Ballester. "USR-VS: a web server
for large-scale prospective virtual screening using ultrafast shape
recognition techniques".
Nucleic Acids Research, 2016.
DOI: 10.1093/nar/gkw320
- HJ Li, KS Leung, MH Wong and PJ Ballester. "Correcting the impact
of docking pose generation error on binding affinity prediction".
BMC
Bioinformatics, 2016.
Manuscript accepted
- XN Shi,
HJ Li, H Yao,
X Liu, LLi, KS
Leung, HF Kung, D Lu, MH Wong, and Marie CM Lin. In silico
Identification and in vitro and in vivo Validation of Anti-Psychotic
Drug Fluspirilene as a Potential CDK2 Inhibitor and a Candidate
Anti-Cancer Drug.
PLoS ONE, 10(7):e0132072, 2015.
DOI:
10.1371/journal.pone.0132072
- HJ Li, KS Leung, MH
Wong and PJ. Ballester. Low-Quality Structural and Interaction Data
Improves Binding Affinity Prediction via Random Forest.
Molecules,
20(6):10947-10962, 2015.
DOI:
10.3390/molecules20061094
- (HJ Li), KS Leung1, MH
Wong1 and PJ Ballester. “Improving AutoDock Vina Using Random
Forest: The Growing Accuracy of Binding Affinity Prediction by the
Effective Exploitation of Larger Data Sets.” Molecular Informatics,
Article first published online: 12 FEB 2015,
DOI:
10.1002/minf.201400132
- XN Shi, (HJ L)i, H Yao, X Liu, L Li,
KS Leung, HF Kung, MH Wong, and Marie CM Lin. "Adapalene Inhibited the
Activity of Cyclin-Dependent Kinase 2 in Colorectal Carcinoma".
Molecular Medicine Reports. (accepted)
- (HJ Li), KS Leung, MH Wong
and PJ Ballester,"Substituting Random Forest for Multiple Linear
Regression Improves Binding Affinity Prediction of Scoring Functions:
Cyscore as a Case Study", BMC
Bioinformatics,
2014, 15(1):291
DOI:
10.1186/1471-2105-15-291
- (HJ Li), KS Leung, T Nakane
and MH Wong. "iview: an interactive WebGL visualizer for protein-ligand
complex". BMC
Bioinformatics,
15(1):56, 2014.
DOI:
10.1186/1471-2105-15-56
- (HJ Li), KS Leung, P.
Ballester, MH Wong. "istar: A Web Platform for Large-Scale
Protein-Ligand Docking",
PLoS ONE 9(1): e85678, 2014.
DOI:10.1371/journal.pone.0085678
- (Hongjian Li), Kwong-Sak Leung, and
Man-Hon Wong. idock: A Multithreaded Virtual Screening Tool for
Flexible Ligand Docking. 2012 IEEE Symposium on Computational
Intelligence in Bioinformatics and Computational Biology (CIBCB),
pp.77-84, San Diego, United States, 9-12 May 2012. DOI:
10.1109/CIBCB.2012.6217214
- (Ching-Man Tse), (Hongjian Li),
Kwong-Sak Leung, Kin-Hong Lee, and Man-Hon Wong. Interactive Drug
Design in Virtual Reality. 15th International Conference on Information
Visualisation (IV), pp.226-231, London, United Kingdom, 13-15 July
2011. DOI: 10.1109/IV.2011.72
(5) Genetic
Parallel
Programming
- Supported by 2 RGC Earmarked Grants
-
We have found that parallel programs can be
evolved
(learnt) faster than sequential ones and have developed a completely
new framework
to evolving parallel programs. It forms a brand new approach in the
field of
Genetic Programming. It has been used
successfully in many applications including hardware design. We have
some
exciting new results which can beat most of the existing
state-of-the-art
algorithms in small circuits’ synthesis. Hopefully we can scale it up!
-
(S. M. Cheang), K. H. Lee and K.S. Leung “Applying Genetic Parallel
Programming to Synthesize Combinational Logic Circuits,” IEEE
Transactions on Evolutionary Computation, Vol.11, No.4,
pp.503-520,
August 2007.
- (Cheang S.M.), Leung K.S. and Lee K.H. “Genetic Parallel
Programming:
Design and Implementation,” Evolutionary
Computation (MIT-Press) Vol.
14 Issue 2, pp. 129-156, 2006
(impact factor: 3.2)
(6)
Learning
Bayesian Network by a new Hybrid
Evolutionary
Algorithm
- One of the fastest and most
accurate hybridised EA
algorithms for learning Bayesian networks
- Successfully applied in many
data mining problems
-M.L. Wong and K.S. Leung, "An Efficient Data Mining
Method for
Learning Bayesian Network
Using an Evolutionary Algorithm-Based Hybrid
Approach", IEEE Transactions on Evolutionary
Computation, Vol.8,
No.4, pp.378-404, August 2004.
(impact factor 3.688).
-M.L.
Wong, ( S. Y. Lee) and K.S. Leung "Data
Mining of Bayesian Networks Using Cooperative Co-evolution" Decision Support Systems. 38,
pp. 451-472. (1.46)
(7)
Non-linear
Integral for Data Mining
Addresses
the issue of dependency of input
attributes successfully in data mining. It has the unique advantage of
recovering
the explicit dependencies among attributes as well as giving high
prediction
rates in classification.
-
(Xu
K.B.), Wang Z.Y., Heng P.A.. and Leung K.S. “Classification by
Nonlinear
Integral Projections” Special Issue on
Knowledge Discovery and Data
Mining, IEEE
Transactions on Fuzzy Systems, (Special issue on Fuzzy
Systems in
Knowledge
Discovery & Data
Mining), Vol.11, No.2, pp187-201,
April 2003.
- (Rong Yang), Z.Y. Wang, P.A. Heng, and
K.S. Leung, “Fuzzified
Choquet integral with fuzzy-valued integrand and its
application on
temperature prediction,” IEEE Trans.
SMCB, Vol.38, no.2, pp367-380,
April 2008.
- K.S. Leung, M.L. Wong, W. Lam, Z.Y. Wang
and (K.B. Xu ) "Learning Nonlinear Multiregression Networks Based on
Evolutionary Computation", IEEE Transactions on Systems, Man
and Cybernetics Part B, Vol.32, No.5, pp.630-644,
October 2002.
(8)
New type of Bayesian Networks
We have invented a new Bayesian network that
addresses the functional relationship problem of the attributes.
-(W.H.
Shum), K.S. Leung, and M.L. Wong, "Learning
Functional Dependency Networks based on Genetic Programming" ICDM'05,
the
proceedings The Fifth IEEE International Conference on Data Mining, New
Orleans, Louisiana, U.S.A., November 27-30, 2005, the IEEE Computer
Society
Press. (full paper, acceptance rate: 10.95%)
**Intelligent Sensor Patent**
(9) Project Management Experience
i. Senior Engineer, ERA Technology, England: Project leader for several international R&D projects (80-84)
ii. System Analyst, Central Electricity Generating Board, England: Responsible for planning, design and coding
of the software of electrical system and generators for nuclear power station real time simulator projects.(84-85)
iii. Managed and developed 8 major computer hardware and software systems) e.g.:
- PI: e-Health Platform with various health sensors such as wireless wearable ECG sensor with AI monitoring developed by our group
- Co-PI:
An integrated web-based air pollution decision support system with 10
different plug-and-play pollutant sensors, including PM2.5, CO2,
radiations, etc.
Our group will
move our attention to creating new algorithms for high impact real-life
genomic
problems such as gene networks acquisition, large scale data mining on
Transcription Factors and Transcription Factor Binding Sites, multiple gene sequence
alignment,
marker extraction, and functional region identification problems. We
have been
working on new data structures, indexing and EAs with dynamic time
warping (DTW) to
solve these
problems. Prof MH Wong who is an expert in database and DTW has been
contributing in this new drive. We are working on real life
Genomic problems on Hepatitis-B, HIV and Diabetes. Drug/Ligand
discovery is also vigorously being pursued.
Bioinformatic
Research Roadmap:
TOP